Drug Uses

Valtrex is indicated for the treatment of herpes zoster (shingles), for the treatment or suppression of genital herpes in immunocompetent individuals and for the suppression of recurrent genital herpes in HIV-infected individuals and is also indicated for the treatment of cold sores (herpes labialis).

How Taken

Valtrex comes as a tablet to take it orally. It is usually taken every 8 hours (three times a day) for 7 days to treat shingles. To treat genital herpes it is usually taken twice a day for 5 days. For cold sores, Valtrex is usually taken for one day only. Do not take more or less of it or take it more often than prescribed by your doctor. Use this medication as soon as possible after symptoms appear. Continue to take Valtrex even if you feel well. Do not stop taking Valtrex without talking to your doctor.

Warnings/Precautions

Do not take Valtrex without first talking to your doctor if you are allergic to acyclovir (Zovirax). Before taking this medication, tell your doctor if you have kidney disease or immune system problems. You may need a dosage adjustment or special monitoring during treatment with Valtrex. Valtrex is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Valtrex passes into breast milk and how it may affect a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you miss a dose of Valtrex, take it as soon as you remember and then take your next dose at its regular time. However, if it is almost time for your next dose, do not take the missed dose. Wait and take the next dose at the regular time.

Possible Side Effects

Kidney failure and nervous system problems are not common, but can be serious in some patients taking Valtrex. Nervous system problems include aggressive behavior, unsteady movement, shaky movements, confusion, speech problems, hallucinations (seeing or hearing things that are really not there), seizures, and coma. Kidney failure and nervous system problems have happened in patients who already have kidney disease and in elderly patients whose kidneys do not work well due to age. Always tell your healthcare provider if you have kidney problems before taking Valtrex. Call your doctor right away if you get a nervous system problem while you are taking Valtrex. Common side effects of Valtrex include headache, nausea, stomach pain, vomiting, and dizziness. Side effects in HIV-infected adults include headache, tiredness, and rash. These side effects are usually mild and usually do not cause patients to stop taking Valtrex. Other less common side effects include painful periods in women, joint pain, depression, low blood cell counts, and changes in tests that measure how well the liver and kidneys work.

Storage

Store at 15° to 25°C (59° to 77°F).Keep Valtrex a tightly closed container. Do not keep medicine that is out of date or that you no longer need. Keep Valtrex and all medicines out of the reach of children.

Overdose

Seek emergency medical treatment if an overdose is suspected. The symptoms of an overdose of Valtrex are not well known, but an overdose of acyclovir (Zovirax), which is a similar drug, may cause seizures, hallucinations, and kidney damage (decreased urine production).

More Information

Herpes infections are contagious and you can infect other people, even during treatment. Avoid letting infected areas come into contact with other people. Wash your hands frequently to prevent transmission. Valtrex will not prevent the spread of genital herpes. Avoidance of sexual intercourse and use of latex condoms may prevent spreading the virus to others.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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The FDA has approved the drug Famvir as the first and only one-day antiviral treatment for recurrent genital herpes and cold sores in people with healthy immune systems. The drug’s maker, Novartis Pharmaceuticals Corp., announced the FDA approval in a news release dated July 28. At least 45 million people age 12 and older in the U.S. have had a genital herpes infection -- or about one in five in that age range, says the CDC. Before, genital herpes required five days of Famvir treatment -- although at a lower dose. Famvir was not FDA approved for cold sores in people with healthy immune systems (meaning those without aids). The new approval shortens Famvir treatment to a single day at the start of an outbreak and adds cold sores to the drug’s approved uses. What’s Your Risk for Genital Herpes? Famvir Dosage Patients would take 1,000 milligrams of Famvir twice daily for one day at the first sign of genital herpes symptoms, and 1,500 milligrams of Famvir once for one day at the first sign of cold sore symptoms to shorten outbreaks and reduce symptoms. The drug, available only by prescription, is taken orally. It does not cure genital herpes or cold sores. Currently, there is no cure for herpes. Antiviral drugs such as Famvir, Zovirax and Valtrex can only help treat or suppress the infection. Famvir earned FDA approval in 1994 and is used to treat shingles, as well as the herpes virus which causes both genital herpes and cold sores. Vaginal Gel Blocks HIV, Herpes Timing Counts Single-day Famvir should be started within six hours of the first sign of symptoms, such as tingling, itching, burning, or the appearance of herpes sores, says Novartis. There is “a narrow window of opportunity for treatment” at the start of an outbreak of herpes or cold sores, says Novartis. Timing is crucial because the virus copies itself most actively in an outbreak’s first hours. Interrupting that process may shorten the outbreak and reduce its severity. Get the Facts on Sexually Transmitted Diseases Herpes Virus There are two types of the herpes simplex virus: herpes simplex virus 1 (HSV-1) and herpes simplex virus 2 (HSV-2). Cold sores are typically caused by the former, which can spread by kissing an infected person or sharing eating utensils, towels, or razors. Genital herpes is a sexually transmitted disease (STD) and is usually caused by HSV-2, although it can result from HSV-1. Most genital herpes patients have few or no symptoms, the CDC notes. When symptoms appear, there are usually one or more blisters around the genitals or rectum. The blisters can break, leaving tender sores that may take several weeks to heal. Clinical Trials Single-day Famvir was tested in clinical trials for treatment of recurrent genital herpes and cold sores. The genital herpes trial included 329 patients. At the first sign of a herpes outbreak, they got one of two treatments, without knowing which they received: 1,000 milligrams of Famvir twice daily for one day A pill containing no medicine (placebo). The Famvir group had milder symptoms and shorter outbreaks that lasted about four days, instead of six days with the placebo, Novartis reports. Single-dose Famvir had a similar effect on the length and severity of cold sores in the cold sores trial, which included 481 patients, according to Novartis. Novartis is a WebMD sponsor.

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