Drug Uses

Skelaxin is a muscle relaxant. Skelaxin is used to treat the pain and stiffness of muscle injuries, including strains, sprains and muscle spasms.

How Taken

Skelaxin comes as a tablet to take by mouth. The recommended dose for adults and children over 12 years of age is two tablets (800 mg) three to four times a day. Skelaxin may be taken with food or immediately after meals to prevent stomach upset. Do not increase your dose, take it more frequently or take it for a longer period of time than prescribed by your doctor.

Warnings/Precautions

Do not take Skelaxin if you have acute intermittent porphyria. Before taking Skelaxin, tell your doctor if you have liver disease. You may need a lower dose or special monitoring during your therapy. It is not known whether Skelaxin will harm an unborn baby. Do not take Skelaxin without first talking to your doctor if you are pregnant. It is also not known whether Skelaxin passes into breast milk. Do not take Skelaxin without first talking to your doctor if you are breast-feeding a baby. Skelaxin is not approved for use in children younger than 12 years of age.

Missed Dose

If you miss a dose of Skelaxin, take as soon as remembered within 1 hour. Otherwise skip that dose and resume usual dosing schedule. Do not "double-up" the dose to catch up.

Possible Side Effects

The most frequent reactions to Skelaxin include nausea, vomiting, gastrointestinal upset, drowsiness, dizziness, headache, and nervousness or "irritability." Other adverse reactions are: hypersensitivity reactions, characterized by a light rash with or without pruritus; leukopenia; hemolytic anemia; jaundice.

Storage

Store Skelaxin at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include severe drowsiness or unconsciousness.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Skelaxin may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Skelaxin.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Data Suggests Taken Alone As Effective As When Taken In Combination With Ibuprofen - Large scale community-based study shows NSAID offers no additional benefit to muscle relaxant in treatment of acute pain and muscle spasm of the back or neck
More is not necessarily better when it comes to treating acute muscle pain and spasm of the back or neck, suggest results from the first community-based trial to evaluate the benefits of adding a non-steroidal anti inflammatory (NSAID) to treatment with a commonly prescribed muscle relaxant. According to the study, the muscle relaxant FLEXERIL 5 mg (cyclobenzaprine HCl), taken three times a day, is as effective alone as when taken in combination with ibuprofen at over-the-counter (OTC) or prescription doses.
More than 770 adult back and neck pain and muscle spasm sufferers at multiple community-based sites throughout the United States completed the randomized, multi-center, open-label one-week study, which compared thrice-daily treatment with FLEXERIL 5 mg alone or in combination with ibuprofen at over-the-counter (1,200 mg/day) or prescription doses (2,400 mg/day). Researchers shared results of the trial today at the 2004 Scientific Assembly of the American College of Emergency Physicians. A final report, including full data on all endpoints, will be completed soon.
"In clinical practice, acute muscle pain with spasm is often treated with an non-steroidal anti-inflammatory drug (NSAID) alone or in combination with a muscle relaxant," explained Martin Childers, D.O., Ph.D., associate professor, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Missouri-Columbia. :The data from this study indicates that the addition of ibuprofen offers no further pain relief compared to taking FLEXERIL 5 mg alone."
About the Study
Men and women between 18 and 65 years of age with acute muscle pain with spasm of the neck or back of up to 14 days participated in the seven-day study conducted by more than 100 physicians. Patients self-reported pain intensity and muscle spasm intensity at baseline and after three and seven days of randomized treatment of FLEXERIL 5 mg three-times-a-day alone or in combination therapy with over-the-counter ibuprofen 400 mg three times a day (tid) or prescription dose ibuprofen 800 mg tid.
Results showed that all three treatments had statistically significant improvements for both spasm and pain from baseline after three and seven days of therapy. Additionally, the changes from baseline were significantly greater after one week of therapy than after three days for all three treatments for spasm and pain. This treatment duration finding was expected and consistent with previous studies. There were no statistically significant differences among the groups.
The types of adverse events observed in this study were consistent with the known safety profiles of these medications.

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