Drug Uses

Paxil is an agent in a newer class of antidepressant medication known as selective serotonin reuptake inhibitors (SSRIs). Depression and anxiety disorders might be caused by a chemical imbalance in the brain. One of these chemicals is serotonin, which helps send electrical signals from one nerve cell to another. In the process, serotonin is released from one nerve cell (the sender) and travels to the next (the receiver), where it is either absorbed or returns back to the original sender cell.

How Taken

Paxil comes as a tablet to take it orally. It is usually taken once daily and may be taken with or without food. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take Paxil even if you feel well. Do not stop taking Paxil without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Warnings/Precautions

Before taking Paxil, tell your doctor if you have liver disease, kidney disease, seizures or epilepsy, or a manic disorder or suicidal thoughts. You may not be able to take Paxil, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Paxil is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take Paxil without first talking to your doctor if you are pregnant or could become pregnant during treatment. Paxil passes into breast milk and may affect a nursing baby. Do not take Paxil without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Paxil and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); an irregular heartbeat or pulse; low blood pressure (dizziness, weakness); high blood pressure (severe headache, blurred vision); unusual bleeding or bruising; or fever or chills. Less serious side effects may be more likely to occur. Continue to take Paxil and talk to your doctor if you experience headache; tremor, nervousness, or anxiety; nausea, diarrhea, dry mouth, or changes in appetite or weight; sleepiness or insomnia; or decreased sex drive, impotence, or difficulty having an orgasm. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store at controlled room temperature between 20-25°C (68-77°F).

Overdose

Seek emergency medical attention if an overdose is suspected. Symptoms of a Paxil overdose include nausea, vomiting, tremor, seizures, agitation, drowsiness, hyperactivity, and enlarged pupils.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Paxil may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness or dizziness while taking Paxil.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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The reports in the New England Journal of Medicine found a higher risk of developmental problems affecting the intestines, brain and skull. Although life-threatening, all of the defects are rare and normally occur in no more than one in 2,500 births. "The take-home message is that we are talking about very small risks," said UC San Diego epidemiologist Christina Chambers, who has studied the effects of antidepressants but wasn't involved in the new research. The studies are the latest to raise concerns about the effects of antidepressants on fetuses. Babies born to women on antidepressants have been shown to experience signs of withdrawal, including tremors and sleep disturbances, during the first days of life. Others studies have linked a mother's antidepressant use later in pregnancy to an increased risk of lung problems in newborns. Two reports have tied the drug Paxil, in particular, to a higher rate of congenital heart malformation. The drug carries a warning about heart defects. The latest studies were the largest yet to analyze the association between antidepressants and birth defects. The findings could complicate decisions by pregnant women about whether to use or continue taking antidepressants, because untreated depression also carries risks and can lead to smoking, drinking and other harmful behaviors. An estimated 10% of pregnant women have depression, according to previous research. Women should not discontinue antidepressants without first talking with their doctors, the researchers said. The studies focused on antidepressants known as selective serotonin reuptake inhibitors, a class that includes Paxil, Prozac, Zoloft and Celexa. The medications work by enhancing the activity of the brain chemical serotonin. They have become the standard treatment for depression since their introduction in the 1980s. In addition to acting on the brain to improve mood, serotonin constricts blood vessels and performs other functions. The full impact of manipulating serotonin levels within the body isn't completely understood, although animal studies have detected a role for serotonin in prenatal development of the heart and head.

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