Drug Uses

Diflucan is indicated for the treatment of:
-Vaginal candidiasis (vaginal yeast infections due to Candida).
-Oropharyngeal and esophageal candidiasis.
-Cryptococcal meningitis.
Diflucan is also indicated to decrease the incidence of candidiasis in patients undergoing bone marrow transplantation who receive cytotoxic chemotherapy and/or radiation therapy.

How Taken

Diflucan comes as a tablet and liquid to take by mouth. It is usually taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Diflucan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid well before each use to mix the medication evenly. Continue to take Diflucan even if you feel well. Do not stop taking Diflucan without talking to your doctor.

Warnings/Precautions

Do not take Diflucan if you are taking cisapride (Propulsid). Combined with cisapride (Propulsid), Diflucan could cause serious, even fatal, heart problems. Before taking Diflucan, tell your doctor if you have any other medical conditions, especially kidney disease, or if you take other medicines. You may not be able to take Diflucan, or you may require a dosage adjustment or special monitoring during your treatment. Diflucan is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take Diflucan without first talking to your doctor if you are pregnant or could become pregnant during treatment. Diflucan passes into breast milk and may be harmful to a nursing baby. For this reason, Diflucan should not be taken by nursing mothers. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Diflucan and seek emergency medical attention or contact your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); liver damage (pale stools, yellowing of the skin or eyes, abdominal pain, unusual fatigue, or dark urine); or a rash. Other, less serious side effects may be more likely to occur. If you experience any of the following side effects, continue taking Diflucan and talk to your doctor: nausea, vomiting, or abdominal pain; diarrhea; headache; dizziness; fatigue; or itching. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store tablets below 86°F (30°C). Protect from freezing. Diflucan injections in Viaflex Plus plastic containers are available in both sodium chloride and dextrose diluents. Store between 77°F (25°C) and 41°F (5°C). Brief exposure up to 104°F (40°C) does not adversely affect the product. Protect from freezing.

Overdose

Seek emergency medical attention if an overdose is suspected. Symptoms of a Diflucan overdose include confusion, hallucinations, paranoia, decreased movement, decreased breathing, tearing eyes, drooling, urinary incontinence, seizures, and death.

More Information

Avoid alcohol or use it in moderation while taking Diflucan. Alcohol and Diflucan can both affect the liver. Use caution when driving or performing other hazardous activities. Diflucan may cause dizziness. If you experience dizziness, avoid these activities.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Uterine Cancer Also called: Endometrial cancer The uterus, or womb, is an important female reproductive organ. It is the place where a baby grows when a women is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer. The symptoms of uterine cancer include * Unusual vaginal bleeding or discharge * Trouble urinating * Pelvic pain * Pain during intercourse Uterine cancer usually occurs after menopause. Being obese and taking estrogen-alone hormone replacement therapy also increase your risk. Treatment varies depending on your overall health, how advanced the cancer is and whether hormones affect its growth. Treatment is usually a hysterectomy, which is surgery to remove the uterus. Other options include hormone therapy and radiation. About the Uterus and Endometrium The uterus is a hollow organ, about the size and shape of a medium-sized pear. The uterus has two main parts. The lower end of the uterus, which extends into the vagina, is called the cervix. The upper part is the body of the uterus, also known as the corpus. (Corpus is the Latin word for body.) The body of the uterus has two layers. The inner layer is called the endometrium. (endo is Greek for inside and metrium is Greek for uterus.) The outer is called the myometrium. (myo is Greek for muscle.) The myometrium is the thick layer of muscle that pushes the baby out during birth. Hormone changes during a woman?s menstrual cycle cause the endometrium to change. During the early part of the cycle, the ovaries (glands on either side of the uterus that produce eggs) produce estrogens. This causes the endometrium to thicken in order to nourish an embryo in case the woman becomes pregnant. After an ovary releases an egg (called ovulation), if pregnancy does not occur, estrogen is produced in lower amounts and more progesterone is made. This causes the innermost layer of the lining to prepare to shed. By the end of the cycle, the lining is shed from the uterus and becomes the menstrual flow. This cycle repeats throughout a woman?s life until menopause (change of life). Cancers of the Uterus and Endometrium Adenocarcinomas: Nearly all endometrial cancers (about 95%) are cancers of glandular cells, called adenocarcinomas. Most of these are described as typical adenocarcinomas. Most experts divide endometrial adenocarcinomas into two types. In type 1, the cancer looks most like normal endometrium and may not be a very dangerous, life-threatening cancer. It only occasionally spreads to other tissues. This type is often called endometrioid, meaning it looks like normal endometrial lining tissue. There are three grades of tumor, with grade three being more aggressive with a greater risk of invasion to the uterine wall (myometrium), local and distant metastases. Sometimes, in addition to glandular cells, endometrial cancers also contain squamous cells (the type of cells found on the surface of the cervix and the skin). If the squamous cells look benign (non-cancerous) under a microscope and the glandular cells look cancerous, these tumors are called adenocarcinomas with squamous differentiation (they used to be called adenoacanthomas, although this term is now used much less often). If the squamous areas and glandular areas both look malignant (cancerous), these tumors are called adenosquamous carcinomas. Although these look different under the microscope, they are treated the same as typical endometrial adenocarcinomas. However, adenosquamous carcinomas tend to be more aggressive. Type 2 endometrial cancer doesn?t look at all like normal endometrium. It is much more likely to spread and is, therefore, more dangerous, These types are called either papillary serous adenocarcinomas or clear cell adenocarcinomas. About 10% of endometrial cancers are these types. Because they are different from the usual kind and tend to grow and spread they are treated more aggressively than the endometrioid cancers. Women with this type of cancer tend to be older by five to ten years on average, than women with type 1. Uterine sarcomas: Uterine cancers that do not come from glandular tissue of the endometrium are called uterine sarcomas. They are less common, but can still involve other parts of the endometrium. These include: * stromal sarcomas, which start in the stroma (supporting connective tissue) of the endometrium * malignant mixed mesodermal tumors (MMMTs or carcinosarcomas), which may combine features of endometrial carcinoma and those of sarcomas * leiomyosarcomas, which start in the myometrium or muscular wall of the uterus These three types of cancer are not discussed in this document because their treatment and prognosis (the outlook for survival) are different from the most common cancers of the endometrium. These cancers are discussed in the document ?Uterine Sarcomas,? which is available from the American Cancer Society upon request or online. Cervical cancers: Cancers of the cervix are different from cancers of the body of the uterus and are described in another American Cancer Society document.

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