Drug Uses

Denavir is a topical antiviral medication used for recurrent cold sores (herpes labialis) on the lips and face in otherwise healthy adult patients. Denavir topical may also be used for purposes other than those listed in this medication guide.

How Taken

Apply Denavir every two hours during waking hours for four days to your cold sore with your finger or a cotton swab. Wash hands with soap and water to prevent it from coming into contact with your eyes or other areas; to prevent irritation and to prevent spread of the herpes virus.

Warnings/Precautions

Denavir is a topical cream that is applied externally on the lips and face. Do not apply Denavir on mucous membranes inside the mouth, nose, genital or rectal areas. Denavir topical is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not use Denavir topical during pregnancy without first talking to your doctor. It is not known whether Denavir topical passes into breast milk. Do not use Denavir topical if you are breast-feeding a baby without first talking to your doctor.

Missed Dose

Use the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and use only your next regularly scheduled dose.

Possible Side Effects

Serious side effects have not been reported with the use of Denavir topical. Other less serious side effects may be more likely to occur. Continue to use Denavir topical and talk to your doctor if you experience: headache; local numbness or tingling where the cream is applied; changes in taste; rash; irritation at the application site. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store at controlled room temperature, 20°-25°C (68°-77°) away from moisture and heat.

Overdose

An overdose of Denavir topical is unlikely to threaten life. If an excessive amount of the cream has been used, or if the cream has been ingested, contact a poison control left or an emergency room for advice.

More Information

Do not use other topical medications to treat the same area at them same time as Denavir topical, unless otherwise directed by your doctor. No other medicines have been reported to interact with Denavir topical. Talk to your doctor or pharmacist before taking other prescription or over-the-counter medications during treatment with Denavir topical.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Gonorrhea Also called: The clap Gonorrhea is a curable sexually transmitted disease. It is most common in young adults. The bacteria that cause gonorrhea can infect the genital tract, mouth or anus. Gonorrhea does not always cause symptoms, especially in women. In men, gonorrhea can cause pain when urinating and discharge from the penis. If untreated, it can cause epididymitis, which affects the testicles and can lead to infertility. In women, gonorrhea can cause bleeding between periods, pain when urinating and increased discharge from the vagina. If untreated, it can lead to pelvic inflammatory disease, which causes problems with pregnancy and infertility. Gonorrhea can pass from mother to baby during pregnancy. You can cure gonorrhea with antibiotics prescribed by your health care provider. Correct usage of latex condoms greatly reduces, but does not eliminate, the risk of catching or spreading gonorrhea. OVERVIEW Gonorrhea is a curable sexually transmitted infection (STI). It is the second most commonly reported bacterial STI in the United States following chlamydia. In 2004, 330,132 cases of gonorrhea were reported to the Centers for Disease Control and Prevention (CDC). When examining race and ethnicity, age, and gender, the highest rates of gonorrhea were found in African Americans, 15 to 24 years of age, and women, respectively. Gonorrhea can spread into the uterus and fallopian tubes, resulting in pelvic inflammatory disease (PID). PID affects more than 1 million women in this country every year and can cause tubal (ectopic) pregnancy and infertility in as many as 10 percent of infected women. In addition to gonorrhea playing a major role in PID, some health researchers think it adds to the risk of getting HIV (human immunodeficiency virus) infection. CAUSE Gonorrhea is caused by bacteria called Neisseria gonorrhoeae. These bacteria can infect the genital tract, mouth, and rectum of both men and women. In women, however, the opening to the uterus (cervix) is the first place of infection. SYMPTOMS The bacteria are carried in semen and vaginal fluids and cause a discharge in men and women. A small number of people may be infected for several months without showing symptoms. For women, the early symptoms of gonorrhea often are mild. Symptoms usually appear within 2 to 10 days after sexual contact with an infected partner. When women have symptoms, the first ones may include * Bleeding associated with vaginal intercourse * Painful or burning sensations when urinating * Yellow or bloody vaginal discharge More advanced symptoms, which may indicate development of PID, include cramps and pain, bleeding between menstrual periods, vomiting, or fever. Men have symptoms more often than women, including * White, yellow, or green pus from the penis with pain * Burning sensations during urination that may be severe * Swollen or painful testicles If left untreated, men could experience prostate complications and epididymitis (inflammation of the testicles). Symptoms of rectal infection include discharge, anal itching, and occasional painful bowel movements with fresh blood in the feces. Symptoms typically appear 2 to 5 days after infection but could appear as long as 30 days. DIAGNOSIS Health care providers usually use three laboratory techniques to diagnose gonorrhea. * Staining samples directly for the bacterium * Detecting bacterial genes or DNA in urine * Growing the bacteria in laboratory cultures Many providers prefer to use more than one test to increase the chance of an accurate diagnosis. You usually can get the staining test results while in the office or clinic. This test is quite accurate for men but not so in women. Only one in two women with gonorrhea has a positive stain. More often, health care providers use urine or cervical swabs for a new test that detects the genes of the bacteria. These tests are more accurate than culturing the bacteria. The laboratory culture test involves placing a sample of the discharge onto a culture plate. The health care provider also can take a culture to detect gonorrhea in the throat. Culture also allows testing for drug-resistant bacteria. TREATMENT Health care providers usually prescribe a single dose of one of the following antibiotics to treat gonorrhea. * Cefixime * Ceftriaxone * Ciprofloxacin * Ofloxacin * Levofloxacin If you are pregnant, or are younger than 18 years old, you should not be treated with certain types of antibiotics. Your health care provider can prescribe the best and safest antibiotic for you. Gonorrhea and chlamydia often infect people at the same time. Therefore, health care providers usually prescribe a combination of antibiotics, such as ceftriaxone and doxycycline or azithromycin, which will treat both diseases. If you have gonorrhea, all of your sexual partners should get tested and then treated if infected, whether or not they have symptoms. Health experts also recommend that you not have sex until your infected partners have been treated. For updated information on treatment for gonorrhea, read the CDC STD Treatment Guidelines. PREVENTION The surest way to avoid transmission of STIs is to abstain from sexual contact or be in a long-term mutually monogamous relationship with a partner who has been tested and is not infected. By using latex condoms correctly and consistently during vaginal or rectal sexual activity, you can reduce your risk of getting gonorrhea and developing complications.

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