Drug Uses

Amoxil is an antibiotic in the class of drugs called penicillin. It fights bacteria in the body. Amoxil is used to treat many different types of infections, such as tonsillitis, pneumonia, ear infections, bronchitis, urinary tract infections, gonorrhea, and infections of the skin. Amoxil may also be used for other purposes.

How Taken

Amoxil comes as a capsule, chewable tablet, liquid, and pediatric drop to take by mouth. It is usually taken every 8 hours (three times a day). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amoxil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Shake the liquid and pediatric drops well before each use to mix the medication evenly. Use the bottle dropper to measure the dose of pediatric drops. The pediatric drops and liquid may be placed on a child's tongue or added to formula, milk, fruit juice, water, ginger ale, or other cold liquid and taken immediately. The tablets should be crushed or chewed thoroughly before they are swallowed. The capsules should be swallowed whole and taken with a full glass of water. Continue to take Amoxil even if you feel well. Do not stop taking Amoxil without talking to your doctor.

Warnings/Precautions

If you have ever had an allergic reaction to another penicillin or to a cephalosporin, do not take Amoxil without first talking to your doctor. Before taking Amoxil, tell your doctor if you have kidney disease, or stomach or intestinal disease. Amoxil is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Amoxil is generally considered to be safe for use during pregnancy. Do not, however, take Amoxil without first talking to your doctor if you are pregnant or could become pregnant during treatment. Amoxil passes into breast milk. Although serious problems have not been reported, rarely, Amoxil may cause a yeast infection, diarrhea, or an allergic reaction in a nursing infant, although no serious harm is expected. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember, and take the rest of the day's doses at evenly spaced intervals. However, if it is almost time for the next regularly scheduled dose, skip the dose you missed and take the rest of the doses for the day as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Possible Side Effects

Contact your doctor immediately if you experience severe or bloody diarrhea and abdominal cramps during treatment with Amoxil. If you experience any of the following serious side effects, stop taking Amoxil and seek emergency medical attention or contact your doctor immediately: an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting); seizures; or unusual bleeding or bruising. Other, less serious side effects may be more likely to occur. Continue to take Amoxil and talk to your doctor if you experience mild nausea, vomiting, diarrhea, or abdominal pain, white patches on the tongue (thrush/ yeast infection); itching or discharge of the vagina (vaginal yeast infection); black, "hairy" tongue or sore mouth or tongue. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Keep out of the reach of children. Store away from heat and direct light. Do not store the capsule or tablet form of Amoxil in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down. Store the oral liquid form of Amoxil in the refrigerator because heat will cause this medicine to break down. However, keep the medicine from freezing. Follow the directions on the label. Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Overdose

Symptoms of an Amoxil overdose may include muscle spasms or weakness, pain or twitching, pain in the fingers or toes, loss of feeling in the fingers or toes, seizures, confusion, coma, or agitation. Seek emergency medical attention if an overdose is suspected.

More Information

Contact your doctor immediately if you experience severe or bloody diarrhea and abdominal cramps during treatment with Amoxil. Take all of the Amoxil that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated. Amoxil may decrease the effectiveness of birth control pills. If you are taking birth control pills, use a second method of birth control while taking Amoxil to ensure protection from unintended pregnancy.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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The Problem of Antimicrobial Resistance Overview Since antibiotics and other antimicrobial drugs first became widely used in the World War II era, they have saved countless lives and blunted serious complications of many feared diseases and infections. The success of antimicrobials against disease-causing microbes is among modern medicine's great achievements. After more than 50 years of widespread use, however, many antimicrobials are not as effective as they used to be. Over time, some bacteria have developed ways to circumvent the effects of antibiotics. Widespread use of antibiotics is thought to have spurred evolutionarily adaptations that enable bacteria to survive these powerful drugs. Other microbes such as viruses, fungi, and parasites have developed resistance as well. Antimicrobial resistance provides a survival benefit to microbes and makes it harder to eliminate infections from the body. Ultimately, the increasing difficulty in fighting off microbes leads to an increased risk of acquiring infections in a hospital or other setting. Diseases such as tuberculosis, gonorrhea, malaria, and childhood ear infections are now more difficult to treat than they were just a few decades ago. Drug resistance is an especially difficult problem for hospitals harboring critically ill patients who are less able to fight off infections without the help of antibiotics. Heavy use of antibiotics in these patients selects for changes in bacteria that bring about drug resistance. Unfortunately, this worsens the problem by producing bacteria with greater ability to survive even in the presence of our strongest antibiotics. These even stronger drug-resistant bacteria continue to prey on vulnerable hospital patients. To help curb this problem, the Centers for Disease Control and Prevention (CDC) provides hospitals with prevention strategies and educational materials to reduce antibiotic resistance in health care settings. According to CDC statistics Nearly 2 million patients in the United States get an infection in the hospital each year About 90,000 of those patients die each year as a result of their infection, up from 13,300 patient deaths in 1992 More than 70 percent of the bacteria that cause hospital-acquired infections are resistant to at least one of the antibiotics most commonly used to treat them People infected with antibiotic-resistant organisms are more likely to have longer hospital stays and require treatment with second- or third-choice medicines that may be less effective, more toxic, and more expensive In short, antimicrobial resistance is driving up health care costs, increasing the severity of disease, and increasing the death rates from certain infections. ENVIRONMENT FORCES EVOLUTIONARY CHANGE A key factor in the development of antibiotic resistance is the ability of infectious organisms to adapt quickly to new environmental conditions. Bacteria are single-celled organisms that, compared with higher life forms, have small numbers of genes. Therefore, even a single random genetic mutation can greatly affect their ability to cause disease. And because most microbes reproduce by dividing every few hours, bacteria can evolve rapidly. A mutation that helps a microbe survive exposure to an antibiotic will quickly become dominant throughout the microbial population. Microbes also often acquire genes from each other, including genes that confer resistance. The advantage microbes gain from their innate adaptability is augmented by the widespread and sometimes inappropriate use of antibiotics. A physician, wishing to placate an insistent patient who has a virus or an as-yet undiagnosed condition, sometimes inappropriately prescribes antibiotics. Also, when a patient does not finish taking a prescription for antibiotics, some bacteria may remain. These bacterial survivors are more likely to develop resistance and spread. Hospitals also provide a fertile environment for antibiotic-resistant germs as close contact among sick patients and extensive use of antibiotics select for resistant bacteria. Scientists also believe that the practice of adding antibiotics to agricultural feed promotes drug resistance.

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